When someone asks the question “Is the brain a computer?”, the answer depends on the knowledge, the person or the system (for example a Large Language Model (LLM)), possesses and whether it is adequate to answer the question. Whether the response is accepted or rejected also depends on the knowledge the receiver possesses. So, it is important to understand the nature of knowledge, how it is acquired (the learning process), and how it is used. General Theory of Information provides a framework for understanding and modeling the representation and use of knowledge in both biological and artificial systems.